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Saline resuscitation markedly reduced plasma oncotic pressure and the plasma oncotic-pulmonary artery occlusion pressure gradient.
Importantly, fasted PPARα -/- mice exhibit markedly reduced plasma glucose levels [30].
One simple interpretation of the SERT data is that Tph1 mice display increased SERT BMAX in lung tissue to maintain optimal levels of intracellular 5-HT in response to markedly reduced plasma 5-HT.
Clotting factor assay revealing markedly reduced plasma factor V activity confirms the diagnosis [ 4].
Cold acclimation markedly reduced plasma levels of adiponectin, and systemic delivery of adiponectin protected ApoE−/− mice from plaque development.
36 Both doses markedly reduced plasma glucose during the FS-MMTT, in contrast to small increases observed with placebo.
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In summary, our results suggest that the intravenous injection in mice of a low dose of an AAV8-based vector encoding the LDLR cDNA generates sustained expression of the LDLR protein in the liver without evidence of hepatic inflammation or toxicity and is highly effective in markedly reducing plasma cholesterol levels and regressing atherosclerosis in a "humanized" murine model of hoFH.
Thiazolidinediones also markedly reduce plasma NEFA [ 127, 139, 172], which would be expected to reduce fatty acyl CoAs and other toxic fatty acid metabolites within arterial smooth muscle cells, thus inhibiting atherogenesis.
Accumulating evidence indicates that clinical treatment of statins may not only markedly reduce plasma LDL-c levels but also significantly improve the clinical outcomes of the patients at high risk of atherosclerosis cardiovascular disease.
Accordingly, treatment with miR-200c-3p miR-200c-3p miR-200c-3pced the plantagomirl of Ang II of H5N1-infected markedlywell (Figureduced
As shown in Fig. 5B, the levels of IGF-1 and FGF-2 which have both been implicated in the anabolic actions of PTH in bone [7], [8] were markedly reduced in plasma from Atf4−/− mice compared to wt mice (P<0.05, wt vs. Atf4−/−).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com