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Compared with control larvae, ezetimibe (50 uM) treated larvae had a markedly reduced number of AM1-43 labeled vesicles in enterocytes of the anterior intestine, the site of lipid absorption in zebrafish larvae (Figure 7A, B).
This was evidenced by a markedly reduced number of sunburn cells after UVR in an inactivated p53 transgenic mouse model.
When tested in a transgenic zebrafish embryonic angiogenesis model, dramatic inhibition in angiogenesis was exhibited by a markedly reduced number of subintestinal vessels.
This is because the advances in the non-surgical rehabilitation of patients with Achilles tendinopathy during recent years have resulted in markedly reduced number of patients awaiting surgery.
Further histological examination of the SA affected testis sections showed markedly reduced number of late meiotic cells and absence of postmeiotic cells.
As a result, Ask1 KO mice had a markedly reduced number of tumor nodules and decreased luciferase activity in lung lysates compared with WT mice (unpublished data, M.K., I.S. and H.I).
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Cell differentiation of E17.5 Creb1−/− lung distal epithelium was analysed by electron microscopy and showed markedly reduced numbers of type-I and type-II alveolar epithelial cells.
Markedly reduced numbers of DCs were also observed in the spleens of patients with sepsis [ 38].
However, compared with WT control mice, mPGES-1 null mice possessed markedly reduced numbers of macrophages in response to bleomycin.
Accordingly, as CCR2 is essential in mobilization of classical monocytes from the BM, these mice also exhibit markedly reduced numbers of circulating monocytes (Serbina & Pamer, 2006).
In Tex14 knockout mice, initially markedly reduced numbers of late meiotic and post meiotic cells are detected and in older animals more severe phenotype with decrease in all germ cell numbers is present [ 15].
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markedly reduced plasma
markedly increased number
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markedly reduced level
markedly reduced cost
markedly reduced macrophage
markedly reduced uPAR
markedly reduced expression
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markedly reduced transmissibility
markedly reduced proliferation
markedly reduced menin
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