Sentence examples for markedly reduced expression from inspiring English sources

Of 20 non-synonymous sequence variants identified only in low absorbers, 14 markedly reduced expression of recombinant NPC1L1 when expressed in CHO-K1 cells.

Crosses of line KS110 to the KNAT1 over-expressing lines resulted in plants with markedly reduced expression of GFP in the o.i.2.

Both of PERK's direct substrates, EIF2A and NRF2, showed markedly reduced expression in transplanted islets.

Immunofluorescence showed a markedly reduced expression of laminin 5 protein whilst expression of collagen VII appeared to be normal.

Knockdown of MS4a4B by selected MS4a4B-siRNAs markedly reduced expression of MS4a4B at both RNA transcription and protein levels (Fig. 2C, 2D and Supplementary Fig. S3C).

Leptin-deficient ob/ob mice show a markedly reduced expression of Pgc-1α in brown adipose tissue, which is reverted by leptin treatment [49].

Analysis of changes in TFF1 produced similar conclusions, with letrozole markedly reducing expression (P = 0.0001) and tamoxifen producing no overall trend in either direction.

In Irf6R84C/R84C mice, keratin 17 expression was markedly reduced, residual expression appearing patchy (Fig.  3H).

Treatment with siRNA specific for either c-Myc or N-Myc markedly reduced ICAD expression without affecting the expression of β-actin.

Sorafenib markedly reduced vWF expression, whereas GdCl3 reduced CD68 expression and the interactions of HSCs and KCs.

Nine of the methylated tumours were estimated to have class 1 BRCA1 protein expression, indicating absent or markedly reduced BRCA1 expression.