Sentence examples for markedly reduced activity from inspiring English sources

Yet, several Kv7.1 channel active compounds exhibit markedly reduced activity when Kv7.1 is co-expressed with KCNE1 [26], [27], [27].

Although highly effective in co-transfection experiments, a markedly reduced activity of each expressed shRNA was observed in transduced cells.

Similar to the TRAP results, human telomerase reconstituted with hTERT Q169A, Q169D, or Q169N exhibited markedly reduced activity compared to the WT enzyme when tested with an 18 nt telomeric ssDNA primer, bio-TELO18 (Figure 2B and Table 1).

In contrast, patients presenting with the so-called atypical subtype of depression are characterised by markedly reduced activity of the HPA axis, while sleep-EEG data suggest that SWA is not reduced and REM sleep parameters are not considerably altered in these patients [7], [15], [17], [28], [29].

As previously demonstrated [ 12], TNF-α markedly reduced activity at this regulatory region consistent with impairment of Sox-9 binding or activity.

Of the two C 9 -aryl substituted derivatives tested (50 and 51) both showed markedly reduC 9 -arylity at the CB2R (50: EC50 = 4300 nM; 51: EC50 > 3000 nM, Table 3).

The bifunctional enzymes, 5-CBM-48 and CBM-48-5, demarkedlyed mareducedreduced activities relative to the wild-type enzymes (two-fold reduction), whereas CBM-5-48 exhibited only a moderate reduction in activity (~15% reduction at the highest concentrations) towards the wild-type enzyme mixture.

DaT scan transaxial SPECT sections for: (a) a patient with essential tremor, showing high symmetric uptake in both caudate and putamen regions; (b) a patient with Parkinson's disease, showing markedly reduced putamen activity and asymmetric caudate activity; (c) a patient with dementia with Lewy bodies, showing nearly absent caudate and putamen uptake.

In addition, two other mutations, p.L228P and p.252delMRT, were reported in the far carboxyl-end of the protein that retained the critical motifs for acyltransferase activity, but had markedly reduced enzyme activity [9,22].

However, acute asphalt fume exposure significantly increased the activity and protein level of CYP1A1 whereas it markedly reduced the activity and protein level of CYP2B1 in the lung.

We further analyzed the activity of GDH, and found that siRNA transfection markedly reduced GDH activity in HEY cells treated with glutamine (Fig. 8C).