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Although the neonicotinic compounds fully inhibited binding of both [α-125I]bungarotoxin to human α7 nAChRs and [3H]cytisine to human α4β2 nAChRs, they were markedly more potent at displacing radioligand binding to human α4β2 nAChRs than to α7 nAChRs.
The reducing power of EDEa was markedly more potent than the hexane and ethyl acetate extracts.
Notably, LDS19 and 21 were markedly more potent, achieving a ∼90-95 ∼90-95tion in infectious titer.
VEGF Trap was again markedly more potent in blocking VEGF-mediated VEGFR2 activation than either ranibizumab or bevacizumab (33 51-fold 33 51-foldt, see Fig. 2; Table 3).
Notably, Esrrb exhibits markedly more potent capacity than other Tcf3 targets to suppress differentiation, sustain propagation, and maintain key pluripotency genes.
Although historic studies of combined androgen blockade have yielded small gains in OS versus ADT alone, the markedly more potent drug combinations now available hold significant promise for increasing the efficacy of multi-targeted AR pathway blockade.
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We found that although both full-length and Gla-less rmGas6 were capable of activating Tyro3, the full-length protein was markedly (∼20-fold) more potent.
By contrast, mutation to produce hFFA2-C4.57G hFFA2-C4.57Geceproducedre although C2 and C3 receptor equipotent, the potency of C5 wherencrealthoughkedly and beC2me significandly (P<0.01) more potent than either C3 oremainedg. 6 D).
In SHR, both formulations markedly reduced systolic blood pressure, AI and TG levels, ZTO being more potent in reversing endothelial dysfunction while was devoid of cardiac stimulatory effect.
Interestingly, the DU145 cell line was also found to be markedly more sensitive to these ansamycin-based compounds in comparison with PC3 cells; GA was 17-fold more potent in DU145 cells, whereas the potency of 17-AAG was 275-fold greater in DU145 cells compared with PC3 cells.
Are Cocktails More Potent at High Altitudes?
More suggestions(15)
remarkably more potent
markedly more severe
substantially more potent
noticeably more potent
considerably more potent
markedly more pessimistic
markedly more hostile
markedly more liberal
markedly more receptive
markedly more acidic
markedly more accessible
markedly more efficient
markedly more diverse
markedly more humble
markedly more confident
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