In ESRD, markedly elevated PTH concentrations (>450-600 predictededicted worse outcomes, whereas a more modest increase did not [ 2, 3, 11, 13].
In grade A and B, CD4+, CD8+, and granzyme B+ T lymphocytes were markedly decreased than that in grade C; however, CD40L+ lymphocytes showed more modest association with the grade.
While the accumulation of these drugs in CSF is markedly increased (300-900%; Figure 3), the effects on cerebral cortex were more modest or even the reverse to that found in CSF.
The rate of gastric emptying was anticipated to markedly affect absorption, particularly in the 'early' time period (AUC60), but to have more modest influence on 'overall' absorption (AUC240).
The monthly rise was far more modest at 1% from July, the data showed, although this was markedly different in London where prices rose 2.7%.
Indeed, it markedly reduced EGF-induced ERK1/2 phosphorylation in A431 cells, but in Caski and C33A cells the reduction was more modest (60 and 20% inhibition, respectively; Figures 3B D), suggesting that persistent signalling through these pathways led to increased survival of Caski and C33A cells, when compared to A431 cells in the presence of cetuximab.
Furthermore, while the differences between the study groups in insulin sensitivity were more modest, the variation in β-cell function at 3 months postpartum was profound, with insulinogenic index/HOMA-IR markedly reduced in women with 1-h GIGT and GDM compared with their peers (Fig. 1 C ).
These associations became stronger with longer lag times and showed differences in subgroup analyses (i.e., the associations were markedly stronger for early-onset Parkinson's disease, particularly for insulin use, vs. the risk for early-onset diabetes and was more modest when oral antidiabetes drugs were used to treat diabetes).
More caution, more prudence, more modest living.
