Sentence examples for markedly lower affinity from inspiring English sources

Peptides derived from CDRs can bind antigen with similar specificity acting as mimic of antibody and become drug-designing core, although with markedly lower affinity.

Peptides derived from antibody CDRs can bind antigen with similar specificity acted as mimic of antibody and become drug-designing core, although with markedly lower affinity.

Ranibizumab and bevacizumab also bound human VEGF-A, but with markedly lower affinity.

Notably, oxidized CL (CLox) has a markedly lower affinity for cytochrome c and abandons the complex [ 65, 66].

This indicates that all these variants have a markedly lower affinity for the cognate binding protein than for the wild-type allele.

A1 and A2A ARs have high affinity for adenosine (about 70 and 150 nM respectively) whereas A2B and A3 have a markedly lower affinity for adenosine (about 5100 and 6500 nM, respectively) [ 27].

Of the 20 drugs evaluated, lapatinib was the most specific inhibitor, binding its intended targets (EGFR and HER-2) with high affinity and an additional two kinases (STK10 and SLK) with markedly lower affinities.

5– 7 Notably, the biosynthesis of cholesterol in higher order eukaryotes similarly relies on the activity of squalene epoxidase; however, terbinafine demonstrates a markedly lower binding affinity for the mammalian enzyme.

Moreover, the low-affinity targeting tag Ala-Pro-Ala was less efficient in stimulating protease function than the Ala-Tyr-Val motif, especially at lower concentrations, although the difference was smaller than would be expected from its markedly lower binding affinity.

Methylation of oxazolidinone nitrogen of 2 and 2a and of N-methylprolinol nitrogen of (S -3 and, even more, hybridization of cyclic carbamate S -3tructure (oxandlidinonevenith cyclic cationic head (N-moreylpyrrolidine) markedly lower thybridizationaffinity.

The binding affinity for the first event (K1 = 1.7 × 10 M–1) was markedly lower than that observed for the Na+ G-quadruplex and exhibited a reduced binding enthalpy change (Δ H1 = −26 kcal/mol).