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The resultant combination of systemic hypotension and vasoplegia blunts the normal redistribution of blood flow usually seen in circulatory shock and markedly limits the host's ability to sustain the vital organ blood flow.
However, due to the delicate nature of the fruit, poor handling practices and inadequate storage facilities, the shelf life of the Chinese bayberry is still short, which markedly limits its market.
In contrast to the genetic simplicity of STS in the first group, the biological and molecular diversity of complex karyotype STS markedly limits the identification of single and specific "oncogenic addiction" aberrations.
Furthermore, the variation in analytical practice markedly limits the value of Ki67 in this context.
If sunlight-avoidance is strictly followed, patients no longer suffer from phototoxicity, but the disease markedly limits outdoor-activities and activities in rooms lit by direct sunlight and thus, it affects social and working capabilities of the patients.
The patient often needs several re-operations, and if surgical debridement is not sufficient a Girdlestone situation is created; the patient then has to function without prosthesis for three to six months, which markedly limits physical activity.
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For his study, Wernig selected patients who had severe but not total cord damage: their ability to move was markedly limited but they were not completely paralyzed.
He introduced a moderate constitution that left much power in the hands of the nobles but markedly limited the absolute powers of the throne.
Taken together, these failings markedly limit the utilization of the Vienna classification of Crohn's disease in clinical trails or disease management.
A poor occurred if the patient had markedly limited activity regardless of the presence of other criteria, any patient with significant pain (requiring narcotics) or a patient with three of the other criteria.
Her activities would be markedly limited.
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