Sentence examples for markedly less sensitive from inspiring English sources

Following pretreatment with IFN- γ, the cells became markedly less sensitive to UK-101, while their sensitivity to general proteasome inhibitors (epoxomicin and dihydroeponemycin) remained unchanged.

ICaL carried by α1c-D was markedly less sensitive to nitrendipine (IC50 17.1 μM) than α1c-wt (IC50 88 nM); a feature exploited to discriminate between engineered and native currents in transduced guinea-pig myocytes.

Likewise the CsAres culture proved markedly less sensitive to both DEB025 and CsA (EC50: 0.46±0.26 µM for DEB025 and 3.77±0.63 µM for CsA).

The instrumental role of SphK1 inhibition in reduced cell growth was confirmed by cell viability assays, which showed that LNCaP overexpressing SphK1 were markedly less sensitive to the effects of androgen depletion (Fig. 3B).

Thymus-derived Tregs are markedly less sensitive than effector T cells to oxidant stress induced cell death [36] and this perhaps suggests a particular role for ROS in Treg function and physiology.

We found that menadione redox cycling by TrxR was markedly less sensitive to NAPQI than disulfide reduction, suggesting that TrxR mediates these reactions via distinct mechanisms.

The inhibition of estrone-3-sulfatase activity in these two subcellular fractions showed a biphasic pattern, with a highly sensitive phase seen at 78 nM to 1.25 μm of PCN followed by a markedly less-sensitive phase at > 2.5 μm of PCN.

Normal neural stem cells were less sensitive than GSCs and sensitivity to UCN-01 markedly increased after in vitro differentiation (Supplementary Figure S2).

EM-2 cell line was most sensitive to cytotoxic drugs, whereas K562 and MOLM-1 were markedly less so.

1H NMR is less sensitive but sample preparation is generally faster and analysis times shorter, resulting in markedly lower analysis costs.

H NMR is less sensitive but sample preparation is generally faster and analysis times shorter, resulting in markedly lower analysis costs.