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The two extracts of S. birrea stem-bark were found to be markedly less potent than ASA as anti-inflammatory agent.
In keeping with previous studies, GLP-1 did stimulate somatostatin release but was markedly less potent than CCK.
Interestingly, five of the seven compounds are markedly less potent against EphB3 than the other three kinases, with two exceptions: CMPD3 and Dasatinib [ 36].
Forskolin increased release 3.3 fold (maximal release 7.2 ± 1.4% of TCC) and A23187 by 1.8 fold (3.8 ± 0.5% TCC), these were markedly less potent than PMA.
Consistent with findings from the signaling studies, LY2784544 inhibited the proliferation of JAK2V617F-expressing cells (IC50=55 nM) and was markedly less potent as an inhibitor of the proliferation of IL-3-stimulated wild-type JAK2 expressing Ba/F3 cells (IC50=1309 nM) (Table 3).
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We found that while wild-type c-Jun markedly increased promoter activity, c-JunbZIP was comparatively less potent (Fig. 5 A); c-Fos activated the promoter less robustly than c-Jun (Fig. 5 B).
Compound 5 was less potent than 1. Cell growth of liver cancer (HepG2) was not markedly affected by these compounds.
French businessmen have become markedly less optimistic.
We are also becoming markedly less religious.
But that made it no less potent.
Trump's other options are less potent.
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