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In the Diabetes Control and Complications Trial study, participants with post-mixed-meal tolerance test C-peptide levels of > 0.2 nmol/l had a 10 mmol/mol (0.9%) lower HbA1c at baseline screening and markedly less incidence of retinopathy, nephropathy and hypoglycaemia [ 76].
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Non-hematological toxicity of the combination appears to be different from the toxicity expected with carboplatin plus paclitaxel, with markedly less neurotoxicity and hair loss, and a higher incidence of mild skin toxicity.
The incidence rate for nausea, the most common adverse effect, was markedly less frequent in elderly subjects when compared to their nonelderly counterparts (17.8% vs 29.4%).
But the incidence of such malcontents is lower than in Europe, whose larger Muslim communities, social science data shows, are markedly less integrated.
French businessmen have become markedly less optimistic.
In contrast, biofortification is markedly less expensive.
We are also becoming markedly less religious.
Yet the judges are markedly less impressed.
People over 55 are markedly less likely to be multitasking.
It was markedly less controversial than health insurance.
De Laurentiis's offer is markedly less demanding.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com