At the middle and lower slope positions, SOC concentrations in the surface soil layer (0 15 cm) markedly declined after intensive tillage, suggesting that the downslope movement of soil by tillage translocated the soil with low concentrations of SOC and TN derived from upslope towards the middle and lower slopes.
We found that the incidence of hypoglycemia was markedly increased by intensive insulin therapy.
In contrast, in a cohort of 339 critically ill patients (11% with a history of diabetes) with stress-hyperglycemia and markedly elevated c-peptide levels, intensive insulin therapy targeting normoglycemia reduced endogenous insulin secretion and normalized c-peptide levels [8].
For example, a recent study by Højberg et al. (10) demonstrated that 4 weeks of intensive insulin treatment markedly improved insulin secretory responses to infused GIP in patients with poorly controlled type 2 diabetes.
In the present context, the proprioceptive input from the arm has been markedly altered by a period of intensive stimulation and the system's response is a gradual shift towards zero in the average response pattern.
During the past decades progress in intensive care medicine has markedly improved the prognosis of sick newborns.
Similar observations have been made for sepsis [ 47], where long-term mortality after surviving the index intensive care stay is markedly elevated.
Because the levels of alcohol consumption by the subjects in the current study are relatively extreme, it is likely that the changes observed in less intensive settings would be markedly less.
Although definitions varied, the incidence of hypoglycemia was markedly greater among patients treated with intensive insulin protocols (30% vs. 14%; RR 3.10, 95% CI 1.54 to 6.23, P = 0.002).
Thus, there were two markedly different therapeutic approaches - that is, intensive gluco- and insulin therapy (liberal glucose intake, or the Leuven approach) and intensive insulin therapy (IIT) (restrictive glucose intake, or the NICE-SUGAR approach) [ 6].
In agreement with previous studies, our meta-analysis demonstrated that intensive insulin therapy carries a markedly increased risk of hypoglycemia.
