Thus, whilst progestins without androgenic action have been found to markedly inhibit these enzymes, an equivalent degree of inhibition is not achieved with testosterone-derivatives.
These results are well aligned with other allelopathy studies of Agropyron repens in which Welbank (1960) found that decaying roots and rhizomes of Agropyron markedly inhibit the root and shoot growth of rape seedlings but no significant inhibition by root secretion.
However, FMNP-labeled MSCs combined with alternating external magnetic field could markedly inhibit the growth of tumor cells in vivo.
The results demonstrated that all synthesized ent-6,7-seco-oridonin derivatives could markedly inhibit the proliferation of cancer cells.
Moreover, overexpression of SREBP-1 by LV-SREBP-1 injection could markedly inhibit the protective effect of DSG against disorder of glucose and lipid metabolism and oxidative stress in GD mice.
The combination of suboptimal concentrations of escin with Cort, which alone could not markedly inhibit the release of inflammatory factors, inhibited the secretion of NO, TNF-α and IL-1β in LPS-stimulated RAW264.7 macrophage cells.
Compound 7b was found to markedly inhibit BTK activity at concentrations of 0.82 nmol/L, as well as to suppress the proliferations of B-cell leukemia cell lines (Ramos and Raji) expressing high levels of BTK at concentrations of 3.17 μM and 6.69 μM.
The combination of low concentrations of Rg1 with Cort, which alone could not markedly inhibit the release of inflammatory factors, inhibited the secretion of NO and TNF-α in LPS-stimulated RAW264.7 macrophage cells, and up-regulated the expression of GR.
Interestingly, the pharmacoligical inhibition of SphK1 did not have any effect on cAMP levels (Fig. 7B) whereas it did markedly inhibit NED (Fig. 7C).
These results signify that the amounts of Rep68 made during the rescue and propagation of the rep68-positive dHVs were not enough to markedly inhibit their production.
Unlike "cytotoxic hypermethylation", gemcitabine did not affect global DNA methylation and did not markedly inhibit cell proliferation at the doses used in our experiments (data not shown).
