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In addition, chromatin immunoprecipitation assays demonstrated that the promoter has a low basal level of histone acetylation, which markedly increases upon treatment of the cells with trichostatin A, further validating the use of this system for screening efforts to identify epigenetic modulators.
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Moreover, YAP/TAZ nuclear accumulation was markedly increased upon wound healing of epidermal injury, and YAP/TAZ depletion was sufficient to impair the rate of wound closure[72].
Although MS4a4B was constitutively expressed in primary naïve T cells, levels of its expression were markedly increased upon stimulation by mitogen concanavalin A (Con A).
Proliferation of V79 cells was markedly increased upon stimulation with all CNTs, except SCNT.
Indeed, activity of PKD was markedly increased upon stimulation with the acetylcholine analog carbachol.
Consistent with this interpretation, the total levels of polyubiquitinated proteins detected in cells were also markedly increased upon ESI treatment.
However, the sensitivity to nickel was markedly increased upon polyamine depletion, a condition that was readily reversed by polyamine supplementation.
Along these lines, the relative abundance of plasma LPC (normalized to total plasma PC), was markedly increased upon EL overexpression (Fig. 5D).
In addition, although total PP2A or Bcl-2 expression is not altered, Bcl-2 phosphorylation is markedly increased upon treatment with PKRI.
We have recently shown by metabolomic analysis that the synthesis of OAS and SMC markedly increased upon L-cysteine deprivation in E. histolytica.
Consistent with previous reports, spontaneous neurite growth of RGCs from AAV2-GFP-treated control mice was markedly increased upon IS compared with ONC alone.
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