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Repression of SOD activity in response to copper was unexpected considering that sod knockouts in S. cerevisiae markedly increases sensitivity to copper and oxygen [60].
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Indeed, whereas Shah and Pishdad (1980) found that lithium induced the hyperglycemia in rats, Tabata et al. (1994) found a markedly increased sensitivity of glucose transport to insulin after lithium treatment.
The knockdown of ASNS markedly increased sensitivity to L-asparaginase, indicating that cells with different ASNS protein levels have different sensitivities to L-asparaginase.
Although showing less than chance accuracy when analyzed with all candidate features, feature reduction with GA and LDA markedly increased sensitivity, specificity and accuracy rates > 80%%.
Studies in aged (24-month-old) rats demonstrated a markedly increased sensitivity to the acute effects of parathion but not chlorpyrifos (Karanth and Pope 2000).
A number of effective concentration or immunologic procedures exist that markedly increase sensitivity of electron microscopic diagnostics for samples with lower particle concentrations (32, 40 ).
This study demonstrates that upregulation of c-Myc levels and activity in colon cancer cells results in markedly increased sensitivity to apoptosis induced by camptothecin.
Expression of NQO1 markedly increased sensitivity to 17-AAG in the OSCC cell lines, while normal fibroblasts, which expressed HSP90 at much lower levels, were more resistant to 17-AAG.
Interestingly, siRNA knockdown of HuR caused a significant elevation in caspase-2L levels and is concomitant with a markedly increased sensitivity of adenocarcinoma cells toward STS- or α-toxin-induced apoptosis.
In addition, we have advanced the Yamazaki method of detecting esterases by using a native electroblot method that markedly increases the sensitivity for detecting esterase activity bands compared to that observed in n-PAGE gels.
The inclusion of amplitude measures markedly increases the sensitivity of detection of a prechiasmal lesion defined as a positive history of ON, with a clear advantage for topographic measures.
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