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Moreover, YAP/TAZ nuclear accumulation was markedly increased upon wound healing of epidermal injury, and YAP/TAZ depletion was sufficient to impair the rate of wound closure[72].
Although MS4a4B was constitutively expressed in primary naïve T cells, levels of its expression were markedly increased upon stimulation by mitogen concanavalin A (Con A).
Proliferation of V79 cells was markedly increased upon stimulation with all CNTs, except SCNT.
Indeed, activity of PKD was markedly increased upon stimulation with the acetylcholine analog carbachol.
Consistent with this interpretation, the total levels of polyubiquitinated proteins detected in cells were also markedly increased upon ESI treatment.
However, the sensitivity to nickel was markedly increased upon polyamine depletion, a condition that was readily reversed by polyamine supplementation.
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Moreover, levels of PGC-1 β transcript and expression of mitochondrial proteins, both structural and belonging to oxidative phosphorylation, were shown to markedly increase upon IR, concordantly with cellular and mitochondrial mass increase.
In addition, chromatin immunoprecipitation assays demonstrated that the promoter has a low basal level of histone acetylation, which markedly increases upon treatment of the cells with trichostatin A, further validating the use of this system for screening efforts to identify epigenetic modulators.
Protein spots in the first group showed markedly increased expression upon Sel treatment and were identified as LAP3 and BAIAP2L1.
However, the residual peripheral T cells themselves showed markedly increased rates of apoptosis upon activation in vitro or in vivo, indicating that Nur77 is an important regulator of mature T cell apoptosis.
Gpa33 –/– mice exhibited hypersensitivity to food antigens and a markedly increased severity of colitis upon exposure to DSS.
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