At first glance, two markedly different diseases, however with increased tissue turnover being a common denominator of both diseases.
DNA binding activity to these sites was markedly increased in tumoral tissue compared to normal tissue, suggesting that this alteration may cause reduced promoter activity of the Na+/I- symporter gene and determine I- uptake deficiency in human thyroid tumors.
TLR2, TLR3, TLR4 and TLR7 expression was markedly increased in synovial tissue from RA patients, compared with synovial tissue from osteoarthritis patients and healthy controls.
In addition, the expression levels of both Adamts5 and Mmp13 were markedly increased in both tissue compartments in the TTR model.
Analysis of mRNA by quantitative PCR revealed that CXCL10 expression was markedly increased in retinal tissue and reached a peak at 6 h after ischemia (175-fold of control).
Costunolide (20 mg/kg) isolated from COS root has significantly decreased glycosylated hemoglobin (HbA1c), total cholesterol, triglyceride, LDL cholesterol, markedly increased plasma insulin, tissue glycogen, HDL cholesterol and serum protein and restored the altered liver enzymes in plasma in streptozotocin induced diabetic rats treated for 30 days [ 42].
In this study, we confirmed that expression of LIN28 mRNA was markedly increased in HCC tissues compared to adjacent non-tumorous liver tissues but was undetectable in normal non-cirrhotic liver tissues.
We observed that expression of the chemokine CCL20 (red staining) was markedly increased in CRC tissues compared with normal mucosa (Figure 3A, B).
We showed that ecSOD expression is markedly increased in ischemic tissues in response to hindlimb ischemia, and that mice lacking ecSOD show impaired post-ischemic neovascularization [17].
Additionally, IFN-γ has been shown to be markedly increased in CNS tissues during HIV-1 infection in the brain and has been implicated in the pathophysiology of HAD [57].
