Sentence examples for markedly increased the amount from inspiring English sources

These funds have markedly increased the amount of money they have raised from investors in recent years, and other kinds of competitors have become more vocal in their criticism.

Induction of immunity is hardly affected by local overexpression, as was shown when injection of AdIL-4 (adenovirus expressing IL-4) in knee joints during arthritis induced by collagen type II markedly increased the amount of inflammatory cells [ 11].

The total surface expression of the high-mannose/hybrid-type N-glycans was also influenced by the immunosuppressive drugs we used; the combination of Rapa and CsA markedly increased the amount of those structures.

This induction was totally prevented by the anti-oxidant NAC, whereas the addition to permeabilized cells of cyclosporin A (CsA), an inhibitor of the pore regulator CyP-D, markedly increased the amount of Ca2+ required to open the PTP.

CMV markedly increased the amount of active calpain-1 and caspase-3 (Fig. 5 A, B ), and this was accompanied by elevated levels of calpain-specific (145 kDa) and caspase-3-specific (120 kDa) spectrin breakdown products (Fig. 5 C, D).

We suggest that the mutation on the consensus splice donor site of exon 6 destroys an ESE motif, which results in a weak splicing signal followed by the skipping of exon 6 together with the targeted exon 5. Transduction of KI NMCMs with AAV6 encoding U7-AON-5 or U7-AON-5+6 markedly increased the amount of Var-4 mRNA (Fig 4).

In addition, cells detached from matrix markedly increase the amount of reactive oxygen species (ROS) in mitochondria.

These results indicate that BVA treatment markedly increases the amount of central 5-HT, especially in the spinal cord, and PCPA prevents such 5-HT increase by BVA.

Dynamic stimulation of cells/gelatine constructs during 14 days (80 cycles/min with a 20% deformation of the initial length) generated a marked increase in cell proliferation, improved spatial cell distribution throughout the scaffold, and markedly increased the total amount of newly synthesized collagen matrix with fibres aligned in parallel to the axis of stress.

Thirdly, knock-down of calsyntenin-1 via RNAi markedly increased the relative amounts of β-CTFs of APP and the secretion of Aβ.

Strikingly, we observed that the addition of increasing amounts of ubiquitinPhospho-Ser65 markedly increased the rate as well as the stoichiometry of phosphorylation of the Parkin Ubl Ser residue reaching ∼0.9 in the presence of 3-fold excess of ubiquitinPhospho-Ser65 relative to Parkin, compared to ∼0.2 without (left panel, Fig 1A).