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Substance dependence likely leads to tolerance, in which markedly increased amounts of a drug (or other addictive substance) must be taken to achieve the same effect.
In a sheep model of septic shock, iNOS inhibition with BYK191023 was superior to norepinephrine in improving microcirculation; interestingly, combined administration of both substances versus single dosing markedly increased the maintenance of arterial pressure and kidney blood flow [ 39].
We demonstrated that pseudopterosin and fuscol biosynthesis can be markedly increased through the addition of the plant bioactive substances.
Correspondingly, chronic camostate feeding markedly increased pancreatic weight, protein and DNA content.
CQ treatment markedly increased the number of surviving neurons with palely stained nuclei and Nissl substance, compared with vehicle-treated gerbils (Figure 3A).
A comprehensive post- 9/11 overhaul means that this figure has probably markedly increased since then.
This markedly increased hospital owners' potential liability.
Conversely, Raptor overexpression-sepsis group markedly increased the AI.
Cluster size markedly increased over time in both conditions.
Properties of nanoparticles that contribute to their usefulness include their markedly increased surface area in relation to mass, surface reactivity and insolubility, ability to agglomerate or change size in different media and enhanced endurance over conventional-scale substance.
But it was the privatised SA Power Networks who'd markedly increased power prices.
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CEO of Professional Science Editing for Scientists @ prosciediting.com