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However, none of these studies reported the markedly increased frequency of CD4+CD25+ and CD25+/FoxP3+CD127- cells found in our study.
In the current study the combination of all these markers was used to characterize and isolate regulatory T cells, confirming our observations of a markedly increased frequency of circulating Tregs in SSc patients.
Taken together, these data suggest that SSc patients have a markedly increased frequency of T regulatory cells, which is not related to an altered expression of markers characterizing Treg phenotype.
Collectively, this data suggests that development of airway responses is associated with a markedly increased frequency of allergen bearing pulmonary mDCs and a concomitantly decreased frequency of allergen-bearing pulmonary pDCs.
Although we observed a markedly increased frequency of CD25+FoxP3+CD127- cells phenotypically representing Tregs in SSc, these patients continue to have active disease suggesting altered T cell suppressive activity.
RA patients experience a markedly increased frequency of cardiovascular disease.
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Furthermore, using newly developed ex vivo INF-γ ELISPOT assays, autoreactive T cell responses to α-MyHC, but not β-MyHC, were observed in the peripheral blood of healthy humans with markedly increased frequencies of α-MyHC-reactive T cells detected in patients with myocarditis [ 13].
Gal-9 markedly increased the frequency of plasmacytoid (p DC-like macrop DC-like4/80+ PDCA-1+ CD11c+), although Gal-9 failed to increase the frequency of cDCs (F4/80- PDCA-1- CD11c+).
Morphine markedly increased the frequency of sEPSCs in pyramidal cells of BLA.
In contrast, chemotherapy not only markedly increased the frequency of dead tumor cells (Figure 2A) but also produced a cumulative increase in DAB4 binding to each dead tumor cell (Figure 2B), and suggested that DNA-damaging drugs induced tumor cell expression of La in vivo.
Males released urine in pulses of short duration (about one second) and markedly increased urination frequency during aggressive behaviour, but did not release urine whilst submissive.
More suggestions(15)
markedly increased occurrence
markedly enhanced frequency
remarkably increased frequency
greatly increased frequency
substantially increased frequency
markedly increased gliosis
markedly increased hematopoiesis
markedly increased power
markedly increased malondialdehyde
markedly increased vascularity
markedly increased muscle
markedly increased risk
markedly increased reactive
markedly increased autophagy
markedly increased hospital
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