The colocalization of LSS with TOMM20 was markedly increased (R=0.856±0.01, Figure 5a, bottom last panel), with concomitant reduction in the overlap of LSS with KDEL (R=0.69±0.02, Figure 5a, second panel from the bottom).
In addition, silencing βTrCP1 in MCF-7 cells markedly increased FOXO3 protein (Figure 2B).
While the accumulation of these drugs in CSF is markedly increased (300-900%; Figure 3), the effects on cerebral cortex were more modest or even the reverse to that found in CSF.
Figure 1 shows that cells grown at higher cell densities had markedly increased cadherin-11 mRNA (Figure 1A) and protein (Figure 1B) expression on a per cell basis compared to those grown at low density.
The presence of 2% MSC cells markedly increased the number of SUM149 mammospheres formed (60 vs. 270, p<0.01) (Figure 2A).
Colony formation assay revealed a markedly increased colony number and size by the overexpression of CENP-A (Figure 4B).
CQ treatment markedly increased the number of surviving neurons with palely stained nuclei and Nissl substance, compared with vehicle-treated gerbils (Figure 3A).
Thus, the IR index calculated from the OGTT was markedly increased in Leptin145E/145E mice (Figure 5C).
In addition, IL-5 level in BALF was markedly increased by Del-N11TCTP (Figure 7D), reflecting the allergenic activity of Del-N11TCTP in vivo.
Distalless and vestigial, which respond mainly to Wg, but also to Dpp [16], [21], were markedly increased by Wg overexpression (Figure 4P and 4Q).
