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Transgenic mice expressing a constitutively active form of human PXR show a markedly increase of UGT activity [ 79].
Lopinavir/ritonavir increased the exposure to lumefantrine markedly (increase of 439%), but conversely decreased the exposure to dihydroartemisinin (decrease of 59.7%).
Similarly, endocan expression by tumorigenic HT29 adenocarcinoma cell line results in a markedly increase of the growth rate of the resulting tumors [ 17].
The relevance for Public Health of the markedly increase of childhood obesity has been recently well highlighted by Burns D et al [ 1].
Anthropometric parameters, blood pressure, NOx- concentration were measured at initial time and after ET. A significant reduction in both systolic and diastolic blood pressure values was seen after ET which was accompanied by markedly increase of NOx- levels (basal: 10 ± 0.9; ET: 16 ± 2 μM).
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Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro.
Loop diuretics markedly increase activation of the renin-angiotensin and sympathetic nervous systems.
In conclusion, this report provides further evidence for the high specificity of markedly increased levels of CSF VEGF in LM.
A second example is the report of markedly increased rates of asthma in primitive villagers from the New Guinea highlands.
The chart shows that this rule, based on a plain majority of countries and of people, markedly increases ease of action.
Duration of miliary TB beyond 20 days tends to markedly increase the risk of ARDS [ 10].
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