However, the LTF gene expression pattern is markedly different in various mammal species as well as in various tissues and cell types.
Thus, ARF4L and GALT3 were markedly expressed in various normal tissues (Nonaka et al, 2002; Tsuda et al, 2002) bearing the potential risk of autoimmune reactions.
As clusterin expression is markedly increased in various benign and malignant tissues undergoing apoptosis, it has been regarded as a marker of cell death.
Among the four types identified to date, we previously demonstrated that plasma membrane-associated ganglioside sialidase (NEU3) is markedly upregulated in various human cancers, including examples in the colon and prostate.
IL-6 is markedly upregulated in various pathologic situations generally associated with pain and hyperalgesia [ 20], and its administration on the skin provokes pain, which increases if it is injected into the cerebrospinal fluid [ 21].
8 NEU3 is markedly upregulated in various human cancers, including colon, 9 renal, 10 ovarian 11 and prostate 12, and contributes to augmentation of malignant properties of cancer cells, probably by causing disturbance of transmembrane signaling.
The reason GIP failed to lower glucose concentrations may relate to antecedent glycemic control, as the insulinotropic effect of GIP is markedly attenuated in various conditions associated with chronic hyperglycemia, such as latent autoimmune diabetes, chronic pancreatitis, and monogenic diabetes (11, 12).
As an additional example, the potent angiogenic factor VEGF is markedly over-expressed in various cell types in the skin of SSc patients [ 55, 56].
However, the observation that macrophage ablation markedly attenuates fibrosis in various conditions suggests that these cells are among the main producers of this growth factor [ 15, 16].
