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At the same time, both treatments markedly improved glucose tolerance and increased insulin immunoreactive levels [57].
HS+MES markedly improved glucose tolerance in high fat-fed mice as indicated by intraperitoneal glucose tolerance test (Fig. 2D).
In contrast HFD-fed BALB/c mice maintained in identical conditions showed both enhanced insulin secretion and markedly improved glucose tolerance, suggesting normal or enhanced insulin sensitivity which may prevent fatty liver in this strain [31].
Strikingly, however, the PDK1K465E/K465E PTEN+/− mice showed markedly improved glucose tolerance compared with PDK1K465E/K465E PTEN+/+ animals.
Moreover, in vivo overexpression of TGR5 in a transgenic (TGR5-Tg) mouse model markedly improved glucose tolerance in mice fed a high-fat diet compared with controls.
However, since overexpression of hepatic RNF20 markedly improved glucose intolerance in diabetic db/db mice (Fig. 8F), we cannot exclude the possibility that hepatic RNF20 might affect glucose metabolism in vivo.
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These data concur with other studies, where chronic combinatorial administration of GLP-1 and GIP analogues in diabetic mice result in markedly improved glucose-lowering and insulinotropic actions compared with either peptide given individually 18.
Exercise induced changes in muscle metabolic pathways have previously been shown to markedly improve glucose uptake and mitochondrial function, in all age groups [ 13].
A delay in gastric emptying in type 1 diabetic patients comparable to that found in healthy subjects markedly improved postprandial glucose excursions in type 1 diabetic patients.
The liver-specific overexpression of constitutively active MAP2K6 (MKK6Glu) in obese ob/ob mice markedly reduced plasma insulin concentrations and improved glucose tolerance [ 28], indicating that reduced Map2k6 expression as detected in B6-Tg(Zfp69) mice might impair glucose homeostasis.
At age 17 years 8 and months, his lipid profile was markedly improved, his fasting glucose was 95 mg/dL, and his 2-h glucose measurement was 121 mg/dL.
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