When hemozoin was injected in mice deficient in IL-1R, neutrophil influx was markedly impaired, implicating a role for IL-1 signalling in attracting neutrophils to the peritoneal cavity (Figure 6a).
However, inflammatory responses during polymicrobial sepsis in mice deficient for MyD88 were markedly reduced implicating the importance of this signal transduction molecule in certain inflammatory scenarios [ 36].
Indigenous people continue to experience poorer health than other people living in the same country 63, and the epidemiological patterns of diabetic disease are markedly different, implicating DIP as a major contributing factor 2. Efforts to reduce these health inequalities have led to an identified need to assess the potential differential impact of interventions 8, 64.
Hyperphosphatemia is commonly found in patients with advanced CKD and has been implicated in the markedly higher incidence of cardiovascular mortality, as well as of visceral and peripheral vascular calcification in these patients [ 20].
Stressed cells markedly enhance RAGE expression which has been implicated in the pathogenesis of a variety of inflammatory diseases including sepsis, diabetes, atherosclerosis, and Alzheimer's disease (6, 8, 9).
Microglial cells have been implicated in AD mainly because of their markedly elevated distribution in brain regions with Aβ deposition, and their pro-inflammatory functions [23].
Consistent with our second hypothesis, qRT-PCR confirmed that at least three genes implicated in the pathogenesis of PAH were markedly up-regulated: Has2, Hapln3 and Retlna.
Endothelial activation is markedly enhanced and associated with disease characteristics that further are strongly implicated in increased cardiovascular risk, and hence constitutes a promising tool in the elucidation of atherogenic mechanisms in RA [ 44- 47].
Interestingly, however, this protein has also been implicated as a regulator of endocytosis and interference with STG markedly slows the rate of vesicle recovery[7] [11].
In addition, several mutations directed at residues implicated in allosteric regulation in Escherichia coli CPS either abolish or markedly suppress complementation and further define the functional importance of the allosteric regulatory region.
Poly(ADP-ribose polymerase (PADP-ribose polymeraseted in DNA rePARP mechasisms and the associated activity shown to markedly increase after DNA damage in carcinogen-treated cells.
