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It is clear, however, that Microsoft's actions markedly impeded Java's progress to that end.
Drug release from the reservoir-type pellets was markedly impeded by the outer EC-based coating layer (EC 1 mg), displaying about 60% of drug release after 8 h, regardless of the acidity of the media.
The progression of metastases into multistep lymph nodes (LN) and internal organs was, markedly impeded in the midway stage and reversed in the ultimate stage following a 20-day course of intravenous immunotherapy [with interleukin-12 (IL-12) gene-engineered mesenchymal stem cells (MSCs), administered once every 5 days P < 0.05)]; the therapy was without systemic toxic effects.
In that study, zoledronic acid treatment markedly impeded intraperitoneal plasmacytoma development.
In this study, zoledronic acid treatment markedly impeded intraperitoneal plasmacytoma development.
Inevitably, regulations like these have markedly impeded any incentive in China to pay greater attention to non-animal toxicity tests.
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Similarly, the addition of dihydrotestosterone (DHT) to androgen-deprived LNCaP cells re-established cell proliferation, through an androgen receptor/PI3K/Akt dependent stimulation of SphK1, and inhibition of SphK1 could markedly impede the effects of DHT.
Resistance of the ETT during expiration can markedly impede lung emptying, worsening with increasing respiratory rate and lung compliance, and with decreasing airway resistance and ETT size.
BE has been shown to markedly impede the migration of several cancer cell types, including lung (lung carcinoma A549 cells) and central nervous system tumours (cell lines C6 glioma and TE671 rhabdomyosarcoma/medulloblastoma) [ 23].
Photoluminescence measurements showed that the core shell nanobelts exhibited a markedly suppressed emission intensity, suggesting impeded recombination of photogenerated carriers as compared to the single-phase counterparts.
More interestingly, BMP2 was able to markedly up-regulate the mRNA levels of Osx, which was impeded by 2BP as well (Fig. 6B), supporting the notion that 2BP inhibits osteoblast differentiation by repressing Osx expression.
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