Sentence examples for markedly impaired the from inspiring English sources
Remarkably, TRIM23 knockdown significantly decreased lipid accumulation and markedly impaired the induction of adipocyte-specific genes.
The lower copper accumulation also suggested that the low expression of CTR1 markedly impaired the influx of DDP in p75NTR+ cells.
The mutation Y6/8A in BST2CD markedly impaired the ability of Vpu to promote virion release, supporting a critical role for this trafficking motif in antagonism of BST2 by Vpu.
Loss of E2F1 expression markedly impaired the TGF β-mediated induction of each of these target genes, indicating that E2F1 is required for TGF β-mediated regulation of its pro-apoptotic downstream target genes.
In a separate mitosis screening study, we found that Cdc5L knockdown markedly impaired the ability of cells to resume mitotic progression after release from treatment with the mitotic inhibitor nocodazole (Supplementary Figures 1a and b).
In vivo administration of CsA or FK506 (AV, ET, MB, CC, and CW, unpublished results), or 11R-VIVIT also markedly impaired the neutrophil bacterial phagocytic killing capacity of UPEC and increased the renal susceptibility to UPEC using an experimental murine model of ascending UTI [ 47].
It makes oral food intake difficult and can markedly impair the quality of life.
The other drugs did not markedly impair the growth of empty vector transformants.
In utero exposure to benzo(a pyrene (10 mg/kg body weight) markedly impairs the fertility of F1 male mice (MacKenzie and Angevine 1981).
Importantly, breast cancer cells from MPA and DMBA-treated RANK-defective mice formed primary but not secondary mammospheres, strongly suggesting that a loss of RANK expression markedly impairs the self-renewal capacity of cancer stem cells [ 30].
However, in the recently released fourth edition of the WHO Guidelines for Drinking-Water Quality (WHO 2011a), the guideline for Mn was discontinued: The 1958 WHO International Standards for Drinking-water suggested that concentrations of manganese greater than 0.5 mg/l [500 µg/L] would markedly impair the potability of the water.
