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The immunohistochemical detection of 4-HNE (another independent marker of lipoperoxidation) in the LV myocardium revealed a markedly higher response in the samples obtained from DAU-treated animals than in corresponding controls.
Silencing of both AhR and Arnt increased 1-NP-induced CXCL8 mRNA expression after 6 h exposure and protein release after 18 h exposure, with a markedly higher response in cells transfected with Arnt siRNA.
These patients, who received PV-10 to all or substantially all of their disease burden, achieved markedly higher response rates compared to patients with substantial untreated disease burden (Table 2).
These effects are notably increased if the cells contain a wild-type p53, suggesting that although p53-independent mechanisms of apoptosis can be triggered by FFCs, the presence of a functional p53 ensures a markedly higher response to treatment.
19 By increasing the percentage of time required to define the responders (75 and >75% rule), we found markedly higher response rates in the mesalazine group compared with the placebo group.
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Moreover, in Japan, Saikawa et al. [12] reported a markedly high response rate in a phase II study of CRT involving S-1 and cisplatin for unresectable gastric cancer.
However, one major problem with the interpretation of these studies is that 9 out of 19 subjects (7 of whom were men) were discovered to have high fasting TG levels (> 150 ml/100 ml); these same individuals had markedly higher lipid and insulin responses, skewing the results.
Addition of nitrate and fumarate suppressed methane production additively in leaves-based diets, and this response was markedly higher for low R C diet than high R C diet.
Indeed, although both α-syn expressing groups recruited CD4+ and CD8+ T cells, this recruitment was retarded in the occurrence of cell death, where the CD8 response was markedly higher.
Both trapezius responses were markedly higher for FM patients vs. HCs in the mental stress test (C) and in Laboratory relaxation (D).
This phenomenon has been previously reported in a Phase II study which showed that HI antibody responses where markedly higher in subjects primed with AS03A-H5N1 vacomparedmpared with those primed with non-adjuvanted H5N1 vaccine [ 23].
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