Immediately after insertion, the dissolution of copper in the uterine fluid is markedly higher ("burst release") than that necessary for contraception action, leading to a variety of harmful effects.
Compared to our study, both Kühn and van de Belt used larger sized samples, which may have influenced the total release[ 14, 15] The importance of carrier size was demonstrated in vivo by Walenkamp; small PMMA-beads established a markedly higher gentamicin release (over 90%) than larger ones.
An increase in the hydrophilicity of the model drugs resulted in markedly higher rates of drug release from the fibers (nadolol>metoprolol>propranolol>tacrine).
The t-PA release rates were markedly higher in subjects homozygous for the I allele [ 9], whereas individual homozygous for the 4G allele has a 25% higher plasma PAI-1 concentration than those with the 5G5G genotype [ 10].
The levels were markedly higher after the weight loss.
Similar effects of ZnSB2 was observed in the soil per se, wherein the rate of release of available Zn by ZnSB2 was markedly higher at all days of incubation (25.6%40.7%% of added Zn), with a peak on the 8th day.
With the exception of IL-8, the level of cytokine release with TGN1412 and muromonab-CD3 was markedly higher compared with other therapeutic mAbs, consistent with CRS severity associated with these therapeutic mAbs.
Silencing of both AhR and Arnt increased 1-NP-induced CXCL8 mRNA expression after 6 h exposure and protein release after 18 h exposure, with a markedly higher response in cells transfected with Arnt siRNA.
In cells exhibiting localised SR Ca2+ release failure, the frequency of spontaneous sparks and embers was markedly higher in regions with re-sealed t-tubules.
Frequency was markedly higher in AF (Ci) and width was lower (Cii), implying a smaller Ca2+ flux per release event on average.
