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The macaque and marmoset lineages exhibited a markedly higher degree of purifying selection.
However, lincRNAs show a markedly higher degree of tissue-specific [ 8] and disease specific expression [ 9], suggesting some biological function.
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Our findings suggest that exposed reefs are susceptible to markedly higher degrees of echinoid bioerosion; however, adequate management measures can significantly reduce these rates, consequently altering the reef's trajectory for degradation.
Histological scoring of the colon revealed more crypt damage and a markedly higher degree and extent of inflammation in DSS-treated WT mice compared to Tg mice (fig. 3b, c).
The markedly higher lethality in WT mice lined up well with the higher degree of necrosis and liver damage in these mice, as assessed by liver histopathology analysis and plasma levels of AST and ALT.
Higher degree of difficulty for sure.
The number of circulating endothelial cells (CECs) is markedly increased in conditions associated with a high degree of endothelial cell activation/injury including PE.
Water-assisted extrusion process has been used to successfully prepare polypropylene (PP /clay nanocomposites with high degree of clay delamination and markedly improved rheological, thermal and mechanical properties.
In addition, organisation of neonatal care differs between countries potentially affecting the generalisability of results from these systems; for example, in Germany neonatal services are markedly deregionalised whereas in Finland and Portugal there is a high degree of regionalisation.
Significantly, despite having a high degree of sequence homology, the different ligands display markedly different clinical effects (Pabreja et al., 2014) leading to speculation of multiple GLP-1 receptor isoforms.
More importantly, in mouse models, exogenous administration of recombinant Il1β induced high degree of bleomycin-induced fibrosis, and specific blockade of Il1r1 markedly reduced bleomycin-induced inflammation [ 16, 17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com