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We observed rapid expansion of blood CD8+ effector cells acutely following VSV therapy with markedly high expression of the immune checkpoint molecules PD-1 and TIM-3.
Markedly high expression that might be caused by gene amplification was observed only in low frequency (<4%) of tumors as shows the last colon in the Table 1.
Similarly, in RA, genes such as KCNAB1 and KCNS1 showed markedly high expression, the latter providing a remarkably clear definition of the nuclear boundary of RA.
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This markedly higher expression level in the progeny is unlikely to be due to the persistence of the little PROS protein detected in the GMC after being divided into the two daughter GCs.
Indeed, most overexpression experiments were done with the X-chromosome-inserted MS1096-Gal4 driver, which results in markedly higher expression levels in males than heterozygous female flies, producing a more penetrant folded wing phenotype in males overexpressing Gαo (see Table 2).
We observed markedly higher expression of CB1 protein in preeclamptic placental tissue.
The reverse (markedly higher expression in treated animals) was never observed.
We also observed markedly higher expression of pro-inflammatory genes in SA1 infected samples in comparison to SA2 infected tissues.
Several of the genes that displayed markedly higher expression in mouse over human beta cells, such as Il1r1 and Pparg, were flanked by mouse-specific novel lncRNAs.
AR+ breast tumors showed a markedly higher expression of PIP (57% ± 6) compared to AR- tumors (16% ± 4), (P <0.01, Figures 2A and 2B).
Many genes were regulated across all tissues and a large fraction of these showed markedly higher expression levels in EM compared to LM (Fig. 3).
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