When endogenous TKT expression is inhibited by siRNA, UM1 and UM2 cells also uptake a markedly higher amount of glutamine.
The markedly higher amount of duplicate reads in the RiboZero libraries compared to the RiboMinus libraries can partly be explained by the much higher sequencing depth of those samples.
We also demonstrated that the different efficacy of RGZ was related to the presence of a significantly higher transcriptional activity of PPAR γ in SK-N-AS compared with SH-SY5Y, which was most likely because of a markedly higher amount of phosphorylated, that is, inactive, PPAR γ in the latter cell line.
Each neoplasm exhibits molecular signatures – sometimes in a patient specific manner – that may completely differ from the organ of origin, may be expressed in markedly higher amounts and/or in different location compared to the normal tissue.
In addition, these cells expressed markedly higher amounts of IFNα compared to uninfected individuals, and were undergoing faster rates of cell death.
This observation can be attributed to the markedly higher amounts of hexon and protease mRNAs generated from the particularly strong MLP, in comparison with the mRNA levels of the other genes.
However, the protein expression level of c-FOS is post-transcriptionally regulated by ERK activation kinetics, where transient ERK signals induced by EGF resulted in little induction of c-FOS, whereas sustained ERK activation by PDGF induced markedly higher amounts of the same protein [ 13, 14].
For example, the markedly higher anthocyanin amounts in the Alaskan potatoes provide a rationale to take advantage of local environmental conditions by growing red- or purple-flesh potatoes.
This showed that the uptake in the receptor-expressing tissues such as the pancreas and colon was markedly reduced by applying a high amount of PEGylated peptide (3.0 nmol).
Blood amylase was found to be markedly high, and computed tomography revealed pancreatomegaly and an increased amount of peripancreatic fat.
