The phrase "markedly exacerbated" is correct and usable in written English
It can be used to describe a situation or condition that has significantly worsened.
Example: "The patient's symptoms were markedly exacerbated after the change in medication."
Alternatives: "significantly worsened" or "greatly intensified."
Atopy and spontaneous peritoneal eosinophilia, characteristic of Lyn−/− mice, were lost in young Lyn−/−STAT6−/− mice; however, autoimmune disease was markedly exacerbated.
Although the local inflammatory environment of the oral cavity has been reported to be markedly exacerbated in diseased subjects [6], [8] [11], the phenomenon, albeit less intense, may also be present in healthy subjects of different ages.
Interestingly, the development of collagen-induced arthritis was markedly exacerbated in Muratin1 KO mice.
It appears from the current study that the increase in expression of matrix remodelling genes is markedly exacerbated by the presence of tumour within the liver.
Nitrosofluorene embryotoxicity was markedly exacerbated by changes in both intra- and extracellular glutathione levels, but definitive dependence on a radical-mediated effect or redox cycling was not demonstrated.
In addition, the amplitude of the calcium increase was markedly exacerbated (** P=0.0019, n=16) in females exposed in utero to ketamine.
Brain hyperthermia markedly exacerbates neuronal injury [ 43].
Specifically, whereas RIP3 blockade protects against autoimmune hepatitis, RIP1 blockade markedly exacerbates disease, and blockade of either necrosome component is protective in APAP.
Data presented here clearly indicate that the complete prevention of PLM phosphorylation at Ser63, 68, and 69 markedly exacerbates remodelling.
We conclude that the lack of endothelial NO production, on its own, is sufficient to markedly exacerbate the severity of septic shock.
Based on the studies in eNOS mice, we conclude that the lack of endothelial nitric oxide production, on its own, may be sufficient to markedly exacerbate the severity of septic shock.
