Thus, upregulation of proton pumps is necessary to generate the slightly alkaline pHi and markedly acidic pHe, which are essential for cancer biology and response to treatment.
Furthermore, frequent glucose measurements, essential for TGC, may markedly increase the workload of ICU nursing staff (13, 14).
This however did not make a lot of sense since heavy pigmentation and excessive hair would markedly reduce cutaneous production of vitamin D3 which was essential for maximizing skeletal health throughout life thereby reducing risk of life-threatening fractures.
However, it is essential for Schizosaccharomyces pombe viability, and its depletion markedly decreased the global protein synthesis in fission yeast [21].
Full-field electroretinography (ERG) is essential for diagnosing RP, which is characterized by markedly reduced or no rod response, and evaluating the disease severity.
RAB5, a small GTPase, is essential for endolysosomal system biogenesis, and RAB5 knockdown markedly reduced the number of early endosomes, late endosomes, and lysosomes, accompanied with a blockage in endocytosis of low-density lipoprotein.
In the present study, nuclear p65 is increased moderately whereas p50 and RelB are increased more markedly (Fig. 8b), and hepatic expression of transcription factors essential for DPG expression are either unaltered or induced in Liv-Ikk2ca mice (Fig. 7).
In Nicotina alata, artificial deletion of two disulphide bonds reveals that one of the bonds is essential for protein binding to trypsin while the other bond markedly decreases the timescale of motion [19].
Interestingly, a closer investigation of these gene families revealed that positive selection signatures markedly characterize diverse proteins involved in pathogen-host interactions, including bacterial secretion, as well as proteins essential for phage defense.
The structural difference between two splice isoforms markedly affects the specificity of ligand receptor binding [7], [8], [9], and exon switching is shown to be essential for development in the mouse [10], [11].
