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Among adults, IRT is markedly elevated with intestinal ischemia/perforation.
HI was markedly elevated with a value of 32.4 ± 8.5.
CLCR measures were markedly elevated, with significant bias reported with both equations.
Fluorescein recovery was markedly elevated with increasing dose of TNFα/IFNγ.
On the contrary, molecular markers of protein degradation, MAFbx (tenfold and sevenfold increases for CMV-8 and CMV, respectively) and MuRF1 (a fivefold increase for both CMV-8 and CMV) mRNA, were markedly elevated with CMV, with and without PEEP.
Since serum CK is markedly elevated with breakdown of muscle and is considered a diagnostic marker of MDs [ 19], we assumed that leakage of transaminases from muscle membrane would occur along with the leakage of CK under pathological conditions, such as in patients with MD.
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Therefore, the markedly elevated serum with only moderately higher hepatic bile acid levels in the double mutant is primarily due to the decreased hepatic uptake.
Hence, the ratio of sympathetic to parasympathetic inotropic responses was also markedly elevated compared with controls (P <.001),.
Absolute values of these biomarkers in these children were markedly elevated compared with non-tropical reference values in nearly all cases.
Levels of intestinal fatty acid binding protein (I-FABP), indicating damage to small intestinal villi, were also markedly elevated compared with healthy European children [ 28].
The plasma level of BH4 in septic patients was indeed markedly elevated compared with that in volunteers (140.0 ± 148.1 vs 24.1 ± 4.8 pmol/ml, P < 0.01).
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