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Male and female homozygotes have markedly elevated serum prolactin levels, and in some instances pituitary hyperplasia is present.
We conclude that patients with primary hyperparathyroidism characterized by markedly elevated serum calcium and parathormone, palpable mass, and severe clinical presentation should be suspected of harboring a parathyroid carcinoma.
The patient's serum Mg level on day 3 was 6.4 mg/dL, and blood drawn at day 1 showed a markedly elevated serum Mg concentration of 16.3 mg/dL (Fig. 2).
Hauty et al. analyzed ten severely hypothermic patients rescued from a snow-covered mountain and resuscitated by CPB, and concluded that hyperkalemia (> 10 mmol/l) and markedly elevated serum ammonia levels (> 250 mcmol/l) predict a dire outcome [8].
Therefore, the markedly elevated serum with only moderately higher hepatic bile acid levels in the double mutant is primarily due to the decreased hepatic uptake.
Pregnant women have markedly elevated serum levels of some hormones, including oestrogens (Cunningham et al, 2001).
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Markedly elevated basal serum hCT levels or pentagastrin-stimulated serum hCT levels higher than 100 pg/ml are thus indicative of MTC.
Women with markedly elevated maternal serum human chorionic gonadotropin levels had significantly increased risks of having spontaneous miscarriage, small-for-gestational-age infants, pregnancy-associated hypertensive disorder, and preterm delivery.
In a subset of mice, NTCP deficiency resulted in markedly elevated total serum BA concentrations, mainly composed of conjugated BAs.
LCN2 has been shown to be markedly elevated in serum and tissues during inflammation (Flo et al., 2004).
One exception may be in homozygous familial hypercholesterolaemia, where a case report has suggested an association between markedly elevated maternal serum cholesterol and fetal intrauterine growth restriction [ 8].
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