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Blood glucose levels of randomly fed coInsm1 animals were markedly elevated, and coInsm1 mice showed pronounced elevation of blood glucose in glucose tolerance tests (Fig 2D and E).
Her D-dimer assay was markedly elevated, and urgent computed tomographic pulmonary angiography (CTPA) was performed (Figures 1 and 2).
The cholesterol content of J774 foam cells was markedly elevated, and the majority of cellular cholesterol was esterified (>80%), as determined by thin-layer chromatography.
Of note, expression levels of MMP-2, MMP-9 and uPA in control HCT116 cells were already markedly elevated and PTEN silencing did not further enhance mRNA levels of these molecules (data not shown).
Cells homozygous for a P-element insertion in the Sec61α gene had markedly elevated and punctate LysoTracker staining as well as punctate localization of GFP-Atg8a (Figs. 5A, B).
As shown in Fig. 4A, pro-inflammatory cytokines including IL-1β and TNF-α were markedly elevated and sustained in plasma of SIV infected macaques thorough 21 days of infection.
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By contrast, diabetic animals and patients with DCM show signs of systemic copper excess with elevations in urinary copper and copper balance, normal or elevated plasma copper and ceruloplasmin levels [ 8, 16, 45, 46], and markedly elevated hepatic and renal copper levels [ 46, 47].
Exposure of islets to STZ shows significantly increased formation of peroxynitrite, NO and ROS with markedly elevated LPO and reduced cell viability.
Given the characteritic CT and MRI features, markedly elevated IgG4 and histopathological findings, the diagnosis of AIP in our case is unambiguous.
In rats, RUPP pressure between days 14 and 19 of pregnancy induces a full pre-eclampsia pregnancy phenotype, including markedly elevated BP and changes in renal artery flow and glomerular filtration rate [ 50].
We and others have shown that patients with SSc-APAH have markedly elevated BNP and N-terminal-pro-BNP (NT-pro-BNP) levels compared with patients with IPAH and patients with non-SSc-CTD-APAH.
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