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Although several humanized anti-CD154 mAbs (hu5C8, IDEC-131 and ABI793) have been developed and shown to be markedly efficacious in nonhuman primate renal allograft models 8– 12, there are significant obstacles to further clinical development.
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This approach has also been adopted in relapsed advanced ovarian cancer with 3-weekly (200 mg m−2) and weekly paclitaxel (67 mg m−2) being demonstrated to be equally efficacious in paclitaxel-naïve patients with markedly fewer toxicities apart from nail changes and lethargy in the weekly arm (Andersson et al, 2000).
Nanotechnology holds great promise in establishing efficacious and innovative strategies to overcome chemoresistance, and markedly facilitate complementary treatments and cancer diagnostics.
We further demonstrate that the LbL nanoarchitecture significantly reduces the elimination rates of both drugs tested and markedly extends their systemic circulation times, paving the way for efficacious tumor drug delivery.
However, our present study results were markedly different than the mere 5.2% of urban Hispanics in the US who perceived that herbs were more efficacious than physician-prescribed allopathic medicines [ 16].
Are the programs truly efficacious?
He should be efficacious.
My faith is something that's efficacious.
Death was Hartley's most efficacious muse.
Fabrications are as efficacious as facts.
"How could you say they are efficacious?
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