Pertussis toxin treatment of cells, by noncompetitively inhibiting Gi signaling, markedly drives the bias toward β-arrestin, and this is readily apparent in the fixed-angle disk model by a shift of points to the first quadrant.
In this case, the expression of RasGRP1 markedly increased ELK driven promoter activity.
Both patients and professionals commented that, prior to the system being introduced, there were sometimes long delays in initiating appropriate treatment in people with less markedly raised BP, driven by reluctance by healthcare staff to prescribe medication which may not be absolutely necessary.
It is hard to believe that was sustainable and driven by markedly higher productivity growth in the UK than in the US.
Furthermore, cancellation of box 2 markedly reduced the activation driven by PGC-1β (7.0±0.5 vs. 1.9±0.5, p = 0.001) or by ERRα (2.2±0.1 vs. 1.6±0.2, p = 0.04), although residual activation was still present.
During the last decades, sheep production in Germany has decreased markedly and has been driven out to low quality pastures or has been used to contribute to landscape conservation (rural environment maintenance) resulting in mainly extensive husbandry of the herds.
Recent research into the cause(s) of HO has been driven by a markedly higher prevalence seen in these wounded warriors than encountered in previous wars or following civilian trauma.
"Sentiment appears to have improved markedly," said Nesvold and that has driven General Motors' stock higher.
Patients with RA experience a markedly increased cardiovascular risk that is driven by metabolic risk factors and by high-grade inflammation [ 7].
The simulation results illustrate the ability of a hydrokinetic turbine driven PMSG to generate electricity markedly better and cheaper than a wind driven PMSG within South Africa.
