Knockdown of mir-30d by its antisense inhibitor AMO-mir-30d markedly diminished the effects of mir-30d, as summarized in Figure 8.
Thus, the magnitude of the autoregressive term was markedly diminished when the effect of large trials was taken into account, while it remained unaltered when other candidate predictors were considered.
Lastly, the effect of the second session was markedly diminished as compared to the effect of the first session, indicating strong anterograde learning interference.
In 1986 Nauck and colleagues reported that the magnitude of the incretin effect was markedly diminished in longstanding T2DM [ 23], and they went on to show that the insulinotropic effect of GIP is also attenuated in this group, while that of exogenous GLP-1 is relatively preserved [ 24].
In patients with type 2 diabetes, the incretin effect is markedly diminished and is less than half that observed in subjects with normal glucose tolerance (NGT) (3).
As shown in Figure 4C, whereas IR exposure of cells resulted in dose-dependent increase in both Chk1 and Chk2 activities, the effect was markedly diminished by the presence of Rac1 inhibition.
In contrast, these diet-induced renal effects were markedly diminished in the ALT group displaying similar levels of expression as CON.
This effect was not observed (in MCF10A) or markedly diminished (in MCF10AT1) in the other two cell lines of the series.
This is in agreement with the observation that truncation of the LFA-1 α subunit cytoplasmic domain has no effect on binding to ICAM-1, whereas binding is markedly diminished by β subunit cytoplasmic domain truncation [ 30].
However, in contrast to its effects on ConA treatment, RIP1 blockade also resulted in markedly diminished APAP injury based on analysis of liver histology and serum transaminases.
Similarly, for depressive disorders, whose symptoms may be considered to be intrinsically impairing (e.g., markedly diminished interest or pleasure in activities), the requirement of impairment had little or no effect on prevalence [ 15, 17– 28, 28].
