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Patient heterogeneity - that is, the fact that patients with ARDS have a wide spectrum of disease severity as well as markedly different underlying pathophysiology (for example, sepsis versus trauma) - has been, and continues to be, a hallmark of ARDS and respiratory failure populations within clinical trials.
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However, sometimes the same LMNA mutation can underlie markedly different clinical phenotypes; cellular and molecular experiments can help to explain the mechanistic basis for such differences.
It is clear from this and other studies that the genes underlying MOTs are markedly different from other ovarian cancer subtypes.
In the case at hand, by contrast, the nature of the underlying constitutional infirmity is markedly different.
Interestingly, although both receptors display convergent effects, pathways underlying CB1 effects are markedly different from those affected by CB2.
We show that the underlying VF dynamics are markedly different between mother rotor and multiple wavelet VF.
Cu forms Cu3Si 3D-islands with markedly different geometries depending on the surface roughness of the underlying H-terminated silicon surface.
14 The authors hypothesized that the pathophysiological mechanisms underlying iron deficiency in heart failure are markedly different from those in chronic inflammatory diseases, a possibility that requires further evidence to be confirmed.
Concurrent results from stochastic DCM for functional MRI data are encouraging (and rather remarkable), and suggest DCM is able to furnish similar underlying functional architectures from data sets with markedly different temporal structures.
Even when group means for multiple sites remain comparable, the underlying correlations between these same sites may be markedly different (e.g. Poirier et al., 2008).
The differences in orientation specificity, and the fact that hysteresis and adaptation display markedly different time constants (Kanai and Verstraten 2005), further speak for a dissociation of their underlying mechanisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com