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Operating on the investigative rhythms of a procedural, with occasional pops of suspense and sudden violence, Zero Dark Thirty shifts into a markedly different mode near the end, following the precise movements of the Seal Team Six mission that actually killed Bin Laden.
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However, the co-crystal structure of BRD4 in complex with dinaciclib revealed a markedly different binding mode (Supplementary Figure S4).
Comparative structural analysis revealed markedly different binding modes of kinase hinge-binding scaffolds in the KAc binding site, suggesting that BET proteins are potential off-targets of diverse kinase inhibitors.
The 3-D structure of I-Ag7 in complex with peptides p509, p524, p530 and p286 revealed two kinds of binding mode; the binding mode of I-Ag7 to p524 and p286 was similar, but markedly different from its binding mode with p509 and p530 (Figure 8).
But the range of rates is markedly different between the two modes.
Structural comparison of H and G glycoprotein β-propellers reveals, however, that, despite having common protein-binding capacities, these two classes of attachment glycoprotein are markedly different in both their architecture and mode of receptor engagement.
In addition to providing a practical detection of c-di-AMP, this work also suggests that coralyne associates with cyclic adenine nucleotides in a mode that is markedly different from the well-characterized complex formation between coralyne and linear polyadenine oligonucleotides.
The books are markedly different in approach and style.
Simultaneous expression of genes encoding HyPRPs with markedly different proline-rich domains might provide multiple modes of interactions between these proteins and the cell wall matrix.
But predictably, for some women in the industry the mood isn't markedly different.
While the sizes of the modes of the bubbles preserved by ash fragments are markedly different for the basaltic versus the dacitic eruption, many complex ash particles preserve both a larger and smaller population of bubbles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com