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The early diagnosis has two main obstacles: 1) the early changes in the tissue's fine structure and delicate functions markedly precede the development of OA as a clinical disease; and 2) current diagnostic imaging has insufficient resolution and unsatisfactory sensitivity to detect early (i.e., small) lesions in cartilage.
Covered with delicate, almost Impressionist brushwork, they are more markedly evocative of Johns-Rauschenberg precursors.
The H5N1-induced hyper-activation of IFN-β and TNF-α pathways synergize to generate a highly pro-inflammatory cytokine/chemokine response that is markedly elevated compared to H1N1 infection and likely tips the delicate balance of the innate immune system towards inflammation, thereby contributing to tissue damage.
Bauer's painting style changed markedly during and after his expedition to Australia with Matthew Flinders (1801 1806), and he favoured a more delicate watercolour style in transparent watercolour [1, 6, 38].
Very delicate.
He had changed markedly.
Her thinking cleared markedly.
The mood dropped markedly.
Turnout was markedly low.
Tempo has slowed markedly.
Security has improved markedly.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com