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We conclude that vezatin recruitment at AJs in MDCKII cells is markedly delayed compared to that of E-cadherin.
We provide evidence that Rab8A GTPase Ser phosphorylation is not directly regulated by PINK1 in vitro and demonstrate in cells the time course of Ser phosphorylation of Rab8A, 8B and 13 is markedly delayed compared to phosphorylation of Parkin at Ser.
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The rate of DNA synthesis was suppressed markedly in the cadmium pretreated group and the first peak of liver regeneration was delayed, compared to the simply partially hepatectomized one.
During RV pacing the septal, as well as the endocardial and epicardial activation times of the left ventricle were markedly delayed as compared to native sinus rhythm.
Clearance was markedly delayed in Hpa-tg compared to Ctr mice.
Due to complete LBBB left ventricular endocardial and epicardial activation was markedly delayed in each patient as compared to control patients (endocardial: 46±19 versus 17±10 ms; epicardial: 49±16 versus 10±8 ms; both p<0.01).
Nlrc4−/− mice exhibited markedly delayed clearance of Lp from the lungs compared to WT mice; a 25-fold difference in lung CFUs was evident at the 72 hour time point and a 10-fold difference persisted to 10 days after infection).
As expected, the addition of the Gomafu repeat oligonucleotides when compared with the control oligonucleotides markedly delayed production of the spliced product (Fig. 4A).
In PIAS4 siRNA knockdown cells, the induction levels of HIF1 α were either decreased as in MiaPaCa2 cells or the HIF1 α induction was markedly delayed with prominent expression only after 48 h exposure to hypoxia in Panc0327 cells compared with controls.
Pramlintide administration markedly delayed gastric emptying in type 1 diabetic subjects (lag period, 60-min retention, and T50, all P < 0.001) compared with placebo, with the most pronounced effects occurring within the initial 60 min after meal ingestion.
Offspring prenatally irradiated with neon ions generally showed higher incidences of prenatal death, increased preweaning mortality, markedly delayed accomplishment in physiological markers and reflexes, significantly lower body weight and reduced ratios of main organ weight to body weight, and altered behavior compared to those exposed to X-rays at doses of 0.1 1.5 Gy.
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