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Immunohistochemical analysis of tumor sections showed that expression of UBXN2A markedly decrease expression of the cell proliferation marker Ki67.
injection of Aβ25 35 could markedly decrease expression of IDE and NEP, but CDS-treated reversed this phenomenon in a dose-dependent manner in mRNA level.
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Astrocytes expressing mhtt transform into reactive phenotype, which is characterized by markedly decreased expression of glutamate transporters (GLAST and GLT-1) and glutamate uptake.
The recellularized hearts also showed disarray of cardiomyocytes and markedly decreased expression of connexin43.
Ribozyme markedly decreased expression of TGF-β1 mRNA and protein in injured vessel.
Ribozyme markedly decreased expression of fibronectin, p27kip1, and CTGF mRNAs in injured vessel, whereas a mismatch ribozyme had no effect on these mRNAs.
In contrast, silencing SPHK1 by RNAi 2, which showed markedly decreased expression of SPHK1, dramatically enhanced UV- or adriamycin-induced cell death in glioma cells (Figures 2C).
Untreated SIV-infected, CD8+ cell-depleted animals demonstrated markedly decreased expression of SYN and MAP2 compared with uninfected controls, while MN-treated animals did not differ from uninfected controls.
Isocitrate dehydrogenase 2 (IDH2), which converts isocitrate to α-ketoglutarate in the Krebs cycle, also showed markedly decreased expression.
In addition, a markedly decreased expression of MMP-2 RNA was present in nodular hepatocytes as compared to normal counterparts.
Yao et al. reported that homozygous Actn4 KI mice showed markedly decreased expression of Actn4 protein in homozygous KI mice, and moderately decreased expression in heterozygous KI mice.
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