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In contrast to the wild-type, AgtA-GFP almost exclusively localized to the plasma membrane in didBΔ cells cultured on glutamate because the labeling of vacuoles seen in the wild-type was markedly less conspicuous in the mutant (Fig. 3A, lower left), strongly indicating that delivery of AgtA to the vacuole is deficient.
The solid arrows point to a small rounded focal lesion, markedly hypointense in all sequences (more conspicuous with the increase of the TE), showing no enhancement with the contrast agent.
Thus, although inactivation of the normal counterpart cascade in wild-type cells can typically be tolerated without conspicuous ramifications, cancer cells (which are inherently less adaptable) often respond markedly to inactivation of their addictive pathway.
If the noughties were about conspicuous consumption by way of designer goods and labels, today's focus is markedly different.
Not conspicuous?
Locally conspicuous.
Too conspicuous.
A conspicuous disparity persists.
Conspicuous consumption is out.
They're so conspicuous.
Cold shoulders became conspicuous.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com