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Intriguingly, sociability was markedly impaired in conditional transgenic lines with either constitutive expression of [ 14] or inducible expression of a mutant DISC1 C-terminal fragment during the early postnatal period [ 15].
Electrophoretic analysis of RNA used for microarray hybridization showed that -ATC, small subunit RNA (18S) is markedly diminished in RPS13 conditional mutants, but large subunit RNA is not (28S) (Figure 7B to D). Ribosomal RNA makes up >80% of total RNA in the cell, therefore rRNA quality and quantity reflect that of the mRNA population.
The genetic analysis also demonstrates that four alleles are not lethal with the entire complementation group but exhibit markedly reduced viability or conditional lethality with certain other alleles suggesting that ATPalpha CJ4, ATPalpha CJ6, ATPalpha CJ7 and ATPalpha CJ12 are likely mild hypomorphic alleles.
Increasing miR-17* level in PC-3 cells by a Tet-on based conditional expression system markedly suppresses its tumorigencity.
This combination of inducible conditional systems leads to markedly reduced viability (as would be expected for Ddc2-depleted cells), and a rapid decrease in Ddc2 levels when cells are treated with tetracycline and auxin.
(The conditional is a condition.
Imperfect regularity in the data structures employed by the TDMP decoder can result in conditional execution and branching which markedly reduces the average utilization of the processor's resources.
Conditional deletion of Sox2 in the mouse epidermis markedly decreases skin tumour formation after chemical-induced carcinogenesis.
However, wogonin markedly inhibited the proliferation of HCT116 cells supported by the conditional medium as shown in Figure 3a.
On the contrary, the test based on the conditional p-value had a probability of rejection markedly smaller than other methods, with both a type I error rate and a power clearly under their nominal value.
It is conditional.
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