Sentence examples for markedly compromise from inspiring English sources

Altogether, these data indicate that perturbations applied to several residues in the S4 helix markedly compromise the ability of KCNE1 to normally regulate Kv7.1 channel gating.

A growing body of evidence shows that a variety of solid human tumors are spontaneously infiltrated by T cells and that memory effector T cells are associated with a favorable clinical outcome while overwhelming regulatory T cells markedly compromise long term survival [1] [4].

Moreover, the fear of falling results in restriction of activities of daily living and can markedly compromise health-related quality of life (HRQoL) [ 9].

However, this degree of hypercapnic acidosis did not markedly compromise circulation; heart rate and arterial pressure increased probably due to increased sympathetic activity, which also could have contributed to the increased pulmonary artery pressure.

Our results demonstrate that overexpression of OsWRKY80 significantly enhanced, whereas suppression of OsWRKY80 by RNAi markedly compromised sheath blight resistance.

Unfortunately in the critical care setting, where organs other than the heart are usually compromised, the specificity of these markers, including tumor necrosis factor (TNF -α, CD-40L, inTNF -αkins (IL-18, IL-6, IL-33, and IL-1a), CRP, fibrinogen, pentraxin 3, and matrix metalloproteinases, are markedly comprominterleukins

For example, highwire mutants display large NMJs but markedly compromised synaptic function [14], [15].

Despite the energetic benefits, contractile function is markedly compromised when β-MHC is increased in the heart [24], [34].

Repeated thawing of the tissue markedly compromised the morphology and the RNA integrity was significantly decreased (p<0.05) after 30 days (Fig. 1B).

Even when the vitelline layer was elevated over the entire surface, the extent of its elevation in the eggs microinjected with RFP-PH was markedly compromised in comparison with the R40A-microinjected eggs (Fig. 7C).

This showed that the KQ mutant was markedly compromised in unloading from DNA.