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Additionally, the expression pattern of hDlg and hScribble, known to control the establishment of apical-basal polarity in epithelial cells [7], markedly changes during colorectal tumor progression with down-regulation of both proteins being associated with lack of epithelial cell polarity and disorganized tissue architecture [8].
The genomic landscape of this histone modification markedly changes during embryonic development at the juncture of stem cell commitment and differentiation; however, its role in later life developmental events is unclear (Bernstein et al. 2006; Pauler et al. 2009; Zhou et al. 2011a).
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The scenario of land use had markedly changed during the years due to the canal irrigation.
In the same way, using %BF is questionable due to its inability to take into account height, lean body mass, or body proportions that markedly change during growth [16].
The quick response (1 2 h) of amoA mRNA transcription to the recovery of ammonia oxidation activity induced by the sudden exposure to ammonia was observed in a short-time batch-mode incubation whereas the amount of amoA DNA did not markedly change during the incubation under any conditions.
The nucleus of epidermal keratinocytes (KCs) is a complex and highly compartmentalized organelle, whose structure is markedly changed during terminal differentiation and transition of the genome from a transcriptionally active state seen in the basal and spinous epidermal cells to a fully inactive state in the keratinized cells of the cornified layer.
Water intake increased or decreased but did not markedly change during this period (Fig. 4b).
The dose of concomitant medication was not markedly changed during this trial.
Thyroid hormone levels markedly change during childhood without showing significant sex differences, except for fT3.
Otherwise, the dose of medication should not be markedly changed during two weeks prior entering into this study.
APP like immunoreactivity was detectable in Western Blot as a single band at approximately 110 kDa (Fig. 2), but did not markedly change during aging.
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CEO of Professional Science Editing for Scientists @ prosciediting.com