Sentence examples for markedly changed in the from inspiring English sources

Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common postoperative complication, despite advances in surgical techniques and intensive care, mortality and morbidity associated with acute renal failure have not markedly changed in the last decade.

Animal studies have confirmed the hypothesis that nicotine pharmacokinetics are markedly changed in the presence of antibodies against nicotine.

The levels of the Core2 subunit of complex III showed no change between groups, indicating that mitochondria density was not markedly changed in the HD context (not shown).

Volume-related parameters, including mean hematocrit values and serum osmolality, were not markedly changed in the present study although some SGLT2 inhibitors have been reported to increase hematocrit values and transiently decrease body fluid volumes [ 5, 9, 10].

Since trastuzumab was accepted as a new agent for breast cancer patients with HER2 over-expressing tumors by the Food and Drug Administration FDAA) in 1998, the strategy of breast cancer treatment has markedly changed in the last decade.

This view was markedly changed in the years thereafter, when targeted experiments with specific immune cells involving hormones of the SNS and hypothalamic pituitary adrenal axis were carried out using cell culture.

However, we found that the levels of p53 and p21 did not markedly change in the presence of C75 or cerulenin in MEFs (Fig. 4A).

Above all, the metabolism of fatty acids respectively lipids is markedly changed in tumors, confirming the early observation of Warburg that tumor cells are characterized by an altered energy metabolism.

There are many different classes of enzymes that can modify nucleosome location and/or chromatin structure that will allow for nuclear receptors to dynamically and transiently bind to chromatin, and this binding can be markedly changed in response to the presence of endogenous and exogenous ligands [ 15- 18].

Moreover, alternative splicing of exons, including the model exon 3 of α-tropomyosin, was not markedly changed in mutant mice, suggesting that the role of raver1 for PTB-mediated exon repression is not absolutely required to generate splice variants during mouse development.

In conclusions, the microbial diversity and community structure markedly changed in different aged workshops which corresponded to the strong flavoring characteristics of Jinhua ham.